The commonly used antihypertensive drugs are divided into five major categories, namely dihydropyridine calcium antagonists, angiotensin-converting enzyme inhibitors, angiotensin II receptor antagonists, diuretics, and beta-blockers. Simple systolic hypertension in the elderly is the most common type of geriatric hypertension, accounting for 60%-80% of geriatric hypertension. Because elderly hypertension has its own characteristics and coexists with a variety of diseases, etc. When treating elderly simple systolic hypertension, diuretics, dihydropyridine calcium antagonists, angiotensin-converting enzyme inhibitors or angiotensin II receptor antagonists should be preferred among the five major classes of antihypertensive drugs, all four of which can be used as the first choice or combined drug therapy, but should start with small doses and the principle of individualization.