If menstruation comes back after 2 years of menopause with breast swelling and pain, it is considered that it may be related to breast hyperplasia, breast cancer, endometrial cancer, etc. You may cooperate with your doctor to receive comprehensive treatments, such as surgery, radiotherapy, chemotherapy, etc., in order to improve your symptoms. 1. Breast hyperplasia: Abnormal estrogen levels in a woman’s body may lead to breast hyperplasia, causing breast swelling and pain, and may also affect the normal growth and shedding of the uterine lining, resulting in a woman’s menstruation again. Medications such as triamcinolone acetonide and dydrogesterone may be used as prescribed by the doctor during the period of the disease to improve the symptoms. If the breast pain caused by breast hyperplasia is more serious or has the possibility of malignant changes, surgery can be considered to remove the hyperplastic tissue. 2. Breast cancer: Abnormal estrogen levels in a woman’s body may also lead to breast cancer. In addition to taking the above anti-estrogen drugs as prescribed by the doctor, it is also necessary to cooperate with the doctor to receive comprehensive treatments such as surgical excision, radiotherapy, chemotherapy and targeted therapy. 3. Endometrial cancer: Increased estrogen level can also lead to endometrial cancer and induce the above symptoms. During the period of illness, one can also take the above anti-estrogen drugs as prescribed by doctor. At present, the main treatment method for endometrial cancer is surgical resection. Combined with chemotherapy, radiotherapy and hormone therapy, it can help to improve the condition. In addition, menstruation with breast swelling and pain after 2 years of menopause may also be a physiological phenomenon. It is recommended to go to the gynecology department of the hospital as soon as possible to complete the relevant examinations, to clarify the cause of the disease and then undergo treatment for the cause of the disease.