Cholestasis generally refers to intrahepatic bile accumulation. Many diseases can cause intrahepatic cholestasis, both biliary obstructive diseases such as cholelithiasis, bile duct cancer, pancreatic head cancer, peripancreatic cancer, biliary atresia; immune system abnormalities such as primary biliary cirrhosis, primary sclerosing cholangitis; and intrahepatic cholestasis during pregnancy caused by hormonal, especially estrogen abnormalities. Intrahepatic cholestasis can present clinically with jaundice, both in the form of yellowish staining of the skin and mucous membranes, as well as darkening of the urine with varying degrees of skin itching. Some patients may also present with symptoms of biliary infection, such as abdominal pain, high fever, and chills. Clinical management also needs to be done in different ways depending on the specific cause of the cholestasis. For autoimmune lesions or intrahepatic cholestasis during pregnancy, the main treatment is pharmacological. For biliary obstructive lesions, surgical or interventional management is the mainstay.