Female urethral syndrome is a group of symptoms that are dominated by frequent, urgent and painful urination. The onset of symptoms varies in severity and recurrence. This syndrome can be caused by a variety of diseases, systemic factors include mental and psychological factors, neurogenic factors, decreased estrogen levels, immune factors and medical factors; local factors include chronic infection of the paraurethral glands and spasm of the external urethral sphincter, variation of the external urethral orifice, such as labia minora fusion, urethral hymen fusion, hymen umbrella, etc.; diagnosis and treatment of this disease need to distinguish the causes, accurate treatment and comprehensive treatment. Clinical manifestations】 1, urinary frequency, urinary urgency, painful urination, often sudden, and rapidly aggravated within a few hours. Urgency of urination, urination can not wait. Severe pain at the urethral orifice and obvious burning sensation in the urethra. Patients complain of fear of drinking and urination. 2. There may be abdominal pain and low back pain, pain in the suprapubic area and kidney area, perineal pain, and discomfort at the entrance of the vagina. 3.Hematuria Small amount of urine is passed each time and there is flesh-eye hematuria or even blood dripping from the urethra. 4.Other symptoms Generally there are no systemic symptoms, occasionally there may be chills and fever, and the symptoms change quickly. The symptoms can be relieved rapidly after the early stage of the disease, and the effect of drug treatment is poor in the later stage. It is easy to attack after drinking less water, fatigue and sexual life. Treatment plan and principles】 A comprehensive treatment plan that combines the cause and symptoms can achieve better results. Treatment of acute attack: 1. Anti-infection treatment Appropriate antibiotic treatment can often relieve the symptoms of attack, commonly used drugs are sulfonamides, macrolides, quinolones, metronidazole, etc.. Chinese herbs for clearing heat, detoxifying and removing dampness also have certain effects. If the urine culture can find the pathogenic bacteria, it can be adjusted according to the drug sensitivity. If the pathogen is found, the corresponding antibiotics should be selected. 2. Symptomatic treatment Pay attention to rest, drink more water, urinate more often and alkalize urine. Clean perineum, vagina, sitz bath, etc. Sedation, antispasmodic, alpha-blocker, etc. 3.Surgical treatment On the basis of infection control, the lesions and foci found must be surgically treated; such as urethral dilatation, urethral distal segment fibrous ring release or incision, urethral episiotomy, urethral caruncle, paraurethral gland cyst, urethral diverticulum excision, etc.. After surgical treatment, anti-infection and symptomatic treatment should be maintained for a period of time. 4.Other treatments According to the different conditions of each patient, other auxiliary treatments can be used. For menopausal women, estrogen therapy can be given if not contraindicated. Some patients can choose physical therapy, such as microwave therapy, hot compresses, etc. Some patients can choose psychological and biofeedback therapy, sedation therapy, local closure therapy, and acupuncture therapy.