Bone metabolism indexes are divided into two categories: bone formation indexes and bone resorption indexes, the former include serum bone-derived alkaline phosphatase, osteocalcin and type I collagen carboxy prepeptide, etc., and the latter include urinary calcium/urine creatinine ratio, pyridinoline, deoxydipyridinoline, and blood tartrate-resistant acid phosphatase (TRAP). 1. Blood bone-derived alkaline phosphatase: It is used to check the activity and function of osteoblasts. If the test value is high, it can be due to physiological reasons such as overgrowth, or pathological reasons such as rickets, hepatocellular carcinoma and cirrhosis of the liver; if it is low, it can be due to anemia, malnutrition and chronic nephritis. 2. Osteocalcin: used to detect bone development and bone metabolism, high results may be related to bone trauma, osteochondrosis, etc., and low results may be related to calcium deficiency and taking certain hormones. 3. Type I collagen carboxy prepeptide: reflecting the specificity and sensitivity of new bone formation, clinically used in the evaluation of anti-bone resorption drugs. 4. Urine calcium/urine creatinine ratio: reflecting the function of bone metabolism, can be used for primary osteoporosis, rickets and other auxiliary diagnosis. 5. Pyridinoline and deoxypyridinoline: high results are seen in patients with tumors, systemic lupus erythematosus, etc., low results are seen in diabetes mellitus. 6. Blood tartrate-resistant acid phosphatase (TRAP): an indicator of bone resorption and osteoclast activity. Increased results can be seen in primary osteoporosis, primary hyperparathyroidism and chronic renal insufficiency. If the above test results are abnormal, it is recommended to consult a specialist for standardized treatment or therapy under the doctor’s guidance.