Blisters (blisters) on the soles of the feet, peeling and itchy, may be caused by diseases such as athlete’s foot and herpes sweating. Antifungal and glucocorticoid drugs can be given. 1. Tinea pedis: Tinea pedis is caused by fungal infections, such as blister-type tinea pedis, resulting in pinpoint-sized blisters between the toes, soles, heels, and lateral margins of the feet. Ketoconazole, clotrimazole, bifonazole and other topical antifungal drugs can be given to inhibit and kill fungal treatment. 2. Sweat herpes: sweat herpes is one of the special types of eczema, occurring on the palms of the hands and soles of the feet, resulting in localized pinpoint-sized blisters. Sweat herpes has a tendency to heal on its own, but is prone to recurrence. Glucocorticoid drugs such as tretinoin urea ointment and halomethasone ointment can be given to accelerate the relief of symptoms and promote the disappearance of blisters by applying them externally. Topical glycerite lotion, boric acid zinc oxide ice tablet ointment, has the role of drying and itching. The soles of the feet long blisters, itching and peeling, it is recommended to the hospital dermatology department, looking for the cause, for the cause of the treatment given, the specific use of drugs need to follow the doctor’s instructions to use.