The difference between povidone-iodine and iodine-ammonium is that iodine-ammonium contains alcohol, which is irritating, while povidone-iodine has a lower concentration, which generally does not cause irritation to the wound. 1. Amyl iodine: Amyl iodine contains a certain amount of alcohol, which may have a certain degree of irritation to the wound surface, causing pain to the patient, so generally Amyl iodine is mainly used for disinfection of the skin without wounds. 2. Povidone Iodine: Povidone Iodine has a lower concentration and is light brown in color, and is generally less irritating, and is commonly used to disinfect the skin, and it is recommended to use Povidone Iodine for skin with wounds, which will rarely cause pain. The difference between povidone-iodine and amyl iodine is the content of alcohol in it. If patients need to use these two medicines, they should use them reasonably under the guidance of the doctor to avoid irritation to the wound and affect the recovery.