MSH6 positivity suggests the expression of MSH6 mismatch repair genes, and this indicator is commonly used in clinical diagnosis and prognosis evaluation of colorectal cancer. Mismatch repair genes are an important component of the DNA damage response pathway and are responsible for maintaining the integrity of the genome, including MLH1, MSH2, PMS2, MSH6 and so on. The proteins expressed by this group of genes are commonly used in the determination of colorectal cancer and whether it is due to microsatellite instability (MSI) mechanisms. Positive expression of MSH6 suggests the presence of a repair system that corrects errors in the process of gene replication and recombination, so that the genetics of the organism are correct and stable, thus preventing tumor malignancy. For specific cases, it is recommended to consult a doctor for further treatment.