Itchy skin on the soles of the feet can be caused by tinea pedis, eczema, etc. It can be treated with topical medication, oral medication, and daily protection. 1. Tinea pedis: manifested as dryness, flaking, blisters, etc. of the feet, and the fungal examination is positive. Anti-fungal drugs can be used externally, such as bifonazole, ketoconazole and so on. When external drugs are ineffective or the lesions are serious, oral itraconazole and other antifungal drugs can be used. 2. Eczema: manifested as foot erythema, papules, sometimes accompanied by flaking, can be used externally halometasone, trimethoprim and other glucocorticoid cream. When itching is obvious, oral antihistamine drugs, such as loratadine. The above drugs need to be under the guidance of a physician, such as itchy skin on the soles of the feet, it is recommended that the regular hospital consultation, after clarifying the condition, targeted treatment.