The treatment of elevated bilirubin in advanced liver cancer needs to be decided according to the specific cause of the disease. The main causes of elevated bilirubin in advanced stage of hepatocellular carcinoma include bile secretion problem of liver cells and bile duct obstruction. 1. Problems of bile secretion by liver cells: patients with advanced liver cancer often combine with severe cirrhosis, which may lead to abnormal bile secretion by liver cells, resulting in elevated bilirubin. At this time, some choleretic drugs, combined with hepatoprotective drugs, such as ursodeoxycholic acid capsule, compound glycyrrhizin, reduced glutathione, etc., can usually be chosen for treatment. 2. Bile duct obstruction: patients with advanced stage of hepatocellular carcinoma may press the hepatobiliary ducts due to huge tumor lesions, resulting in bile can not be discharged smoothly, thus causing bilirubin elevation. At this time, it is feasible to perform biliary puncture to drain out the stagnant bile, and it is also possible to put in biliary stent and other measures to dilate the bile ducts, so as to restore the normal drainage of bile. When elevated bilirubin is found in patients with advanced stage of liver cancer, it is recommended to go to the hospital in time and take treatment under the guidance of doctors, so as to avoid delaying the condition.