The persistence of high blood pressure that does not come down may be due to the persistence of poor lifestyle, drug tolerance, and secondary factors that affect blood pressure. Accordingly, we can change the bad lifestyle, adjust antihypertensive drugs, and treat the primary causes of hypertension. 1. Change the bad lifestyle: including smoking, drinking, obesity, high salt diet, long-term use of contraceptives and other factors. The long-term persistence of these bad lifestyles may lead to poor blood pressure control. Patients can try to change these bad lifestyles by quitting smoking and drinking, exercising moderately to reduce weight, and reducing the intake of salt in food. 2. Adjustment of antihypertensive drugs: long-term use of an antihypertensive drug may lead to poor control of blood pressure due to drug resistance, patients can try to combine with other antihypertensive drugs or adjust the replacement of antihypertensive drugs. 3. Treating the primary cause of hypertension: there are two types of hypertension: primary and secondary. If long-term hypertension does not come down, we should consider whether it is caused by secondary factors. If the hypertension is caused by secondary causes, we should actively treat the primary causes of hypertension, such as kidney disease, endocrine disease and so on. Only by curing the pathogenic diseases that cause hypertension can the blood pressure be controlled fundamentally. There are many medications for treating hypertension, and there are also many primary diseases that cause hypertension. In order to avoid the adverse consequences of long-term hypertension, it is recommended that patients consult a doctor in a timely manner to adjust antihypertensive drugs under the guidance of a specialist, or complete detailed examinations to rule out secondary hypertension.