Esophageal papillomas are benign tumors of epithelial origin in the esophagus that are generally small in diameter, rarely cause symptoms, and are often discovered during esophagoscopy and gastroscopy. Endoscopically, it may appear as a coral and blackberry-like bulge protruding into the lumen of the esophagus. If the papilloma is large in diameter, a microscopic biopsy can be performed first, and pathologic examination can be performed after obtaining the diseased tissue to determine the specific nature of the papilloma, and then endoscopic resection can be performed at a later stage. If the size of the papilloma is relatively small, you can also directly perform endoscopic biopsy forceps removal or high-frequency electrolysis before the tissue specimen for pathological examination. Regular follow-up esophagoscopy and gastroscopy must be performed after papilloma removal to avoid recurrence of papilloma. Generally, the chance of papilloma appearing malignant is relatively small, belonging to a kind of benign tumor of a better nature.