Gynecomastia is also known as “male breast enlargement” or “gynecomastia”. It refers to the enlargement of one or both breasts in men, with sentencing nodules palpable under the areola, often with fibrous tissue and fat tissue hyperplasia, and with swelling and pain or tenderness. Sometimes accompanied by breast swelling and pain, is a common clinical gynecomastia, almost at any age in men, often recognize temporary and self-limiting. It is an endocrine disease. This disease belongs to the category of “breastē¬” in traditional Chinese medicine. Clinically, it is especially common in adolescence and old age. Breast development in newborns is mostly bilateral, sometimes accompanied by nodules, which may be related to the influence of estrogen in the mother’s body, and can generally subside on its own after a few weeks, and occasionally last for several months, or even several years. In pubertal boys, it is reported that more than 64% of the disease occurs in varying degrees, the age of onset is mostly 12-17 years old, with a peak at the age of 14 years, the typical course of the disease is 1-2 years, and about 3/4 of the patients show bilateral involvement. The majority of patients present with adenomatous or diffuse disease. These patients are also referred to as “idiopathic gynecomastia”. These patients often have localized pain and tenderness, and the size of the nodules is usually less than 75px in diameter, with a few being more than 125px. This type of patients generally do not need treatment, some patients are nervous, so avoid normal social activities, resulting in serious psychological problems, sexual surgery can be considered. Elderly gynecomastia, the patient’s age is mostly in 50-70 years old, such patients initially for one side of the mammary hypertrophy, then appeared on the opposite side of the enlargement, and some of them can be disappeared within a year. There are also some pathological factors: gonadal underdevelopment, endocrine dysfunction, liver disease, chronic renal insufficiency, malignant tumors (lung cancer, testicular cancer, embryonic cancer, teratocarcinoma, choriocarcinoma, hepatocellular carcinoma, gastric carcinoma, renal carcinoma, etc.). Drug factors: many drugs can be the cause of abnormal development of male breast, such as: estrogen, progesterone, testosterone, gonadotropin, chlorpromazine, cimetidine, gastroenterology (metoclopramide), metronidazole, isoniazid, ethambutol, risperidone, spironolactone (Antibiotics), paxillin, leucovorin, methadone, acetone, sodium phenytoin, carbamazepine, iodine ketone, calcium channel blockers, tricyclics. antidepressants, digitalis, amphetamines, and phenothiazines. Abnormal male breast development of relatively short duration can usually be recovered once the cause is recognized and effective treatment is given. Surgery is generally not taken, unless the breasts are too large, swelling and pain is obvious, affecting the beauty, and even causing patients’ mental anxiety, while drug treatment is ineffective, and the patient insists on surgery. Most patients are given at least two years of observation before surgery to allow it to subside on its own.