Over the years, I have seen many patients with ankylosing spondylitis in my outpatient clinic, and most of them are young people. Upon hearing that they have ankylosing spondylitis, many young people become very desperate, and their family members accompanying them also become very anxious, with a sense of fear. The reason for this is that for a long time there is a folk saying that ankylosing spondylitis is an incurable disease! With the passage of time, the condition will become more and more serious, the patient is very painful, and some people even call it “immortal cancer”. Is this true? Ankylosing spondylitis (hereinafter referred to as “ankylosing spondylitis”) is a systemic autoimmune disease that can affect many parts of the body. Inflammation occurs mainly in the tendons, ligaments, joint capsules and other attachments on the bones, so some people call it “attachment point inflammation”. As the disease progresses, the prolonged inflammation leads to scarring and ossification of the soft tissues, which ultimately leads to stiffness of the joints and ankylosis of the spine, making the patient’s life very difficult, and in severe cases, the patient almost loses the ability to take care of himself/herself. Simply put, the harms of chiropractic include low back pain, stiffness and limited movement of the entire spine, or a variety of deformities – the most common are the humpback deformity, hip ankylosis deformity, followed by the knee joints, ankle joints, and the joints of the upper limbs are less often involved. The causes of ankylosing spondylitis are not well understood, but one of the main “culprits” is an inflammatory factor called “tumor necrosis factor”, which triggers synovitis and activates osteoclasts, resulting in persistent inflammation, bone destruction, and joint deformity. In the early stages of the disease, the main manifestation is low back pain, and in most cases lumbosacral joint pain, which can also be accompanied by neck and shoulder pain, pain in the hips, leg pain, knee pain and so on. This pain is mostly characterized by night, especially in the early hours of the morning or when I get up, so I often call it “cock-crowing pain”. After daytime activities, the pain is reduced. This is because the slow blood flow at night, inflammatory factors in the lesion accumulation, resulting in the most obvious pain; daytime activities due to increased blood flow, the local inflammatory factors dissipate, contributing to the reduction of pain. In the middle and late stages of the disease, the condition becomes more and more severe: generally speaking, the spine gradually fuses from the bottom to the top, and eventually either becomes a “straight stick”, or is severely hunched over, or even unable to lift the head. The typical “dendritic changes” appear on X-rays, and in the majority of cases there is fusion of the sacroiliac joints (Fig. 2); the neck is not able to rotate flexibly, and if someone calls from behind, it is impossible to turn back, but only to turn the whole body around slowly; and if the hip joints are involved, the patient may become hobbling when he walks. Strong chiropractic occurs in young adults between the ages of 14 and 30, and can even be seen in children as young as 12 or 13 years old, with males accounting for about 90% of cases. It is not a hereditary disease, but it runs in families. In other words, if a father or mother has the disease, his or her children do not necessarily have the disease, but the risk of developing it is greater than normal. The reason for this is that the vast majority of patients with Gastroparesis carry certain specific disease-causing genes, which have a certain chance of being passed on to their offspring; at the same time, whether or not the gene is expressed is affected by environmental factors. Repeated gastrointestinal infections have been shown to be a risk factor for the expression of the disease-causing gene. One of the products of the gene is a protein called human leukocyte antigen B27, or HLA-B27, so when a blood test is positive for HLA-B27, it is likely that the body carries the gene. However, this link is not 100% – about 90% of patients with ankylosing spondylitis are HLA-B27 positive, and about 5% of the normal population is also HLA-B27 positive. At the same time, HLA-B27 positivity alone does not lead to a diagnosis of ankylosing spondylitis, because HLA-B27 is not exclusive to ankylosing spondylitis, but can also be positive in other diseases. In the past few decades, we could only adopt symptomatic treatment for the disease, i.e. anti-inflammatory and pain relief, and could not slow down the progression of the disease. Therefore, once one suffers from this disease, it is difficult to avoid the development of the disease to the middle and late stages within a few years or a decade, and the patient will suffer great physical and mental devastation. From this point of view, in the past it was called “incurable disease” has a certain reason. I have been admitted to a number of patients with chiropractic, are manifested as the spine and lower limbs ankylosis, complete loss of self-care ability. The disability rate of chiropractic can be up to 15% or so. However, with the introduction of “biological agents”, chiropractic is no longer at the mercy of doctors. Unlike traditional medications, biologics are a class of artificially recombined macromolecular proteins. Nowadays, there are three main types of biologics in common use, representing drugs such as “Enli”, “Xumel”, “class of grams”, etc. They have different mechanisms of action. Their mechanisms of action are different: “Enli” acts as a “trap” receptor of “tumor necrosis factor”, preventing “tumor necrosis factor It prevents tumor necrosis factor from binding to its real receptor, thus blocking the key link of inflammation and rapidly and effectively slowing down the progression of the disease and even curing it to a certain extent; “Xumeluo” and “Classical” can prevent tumor necrosis factor from binding to its real receptor by “capturing” the tumor necrosis factor. “capturing” “tumor necrosis factor” to prevent it from playing its role. In recent years, more clinical studies have shown that “Enli” has better and more sustained efficacy and better safety. There are many patients who have been found to have strong chiropractic mental stress, we used the biological agent for them, one or two months to review, the symptoms have greatly improved, the mood is also much more relaxed. It can be seen that nowadays, it is very outdated to call the disease “immortal cancer”. As long as early diagnosis and treatment are made, the disease can be effectively controlled, the symptoms are basically relieved, and the work and study can be carried on as usual.