Pain in the area from the testicles to the root of the penis may be caused by a variety of reasons such as urethral trauma, prostatitis, epididymitis, varicocele or testicular tumor. 1. Urethral trauma: If anterior urethral injury occurs, there may be urethral bleeding, difficulty in urination, local hematoma and pain, and the pain may be located in the perineum, scrotum and other places. 2. Prostatitis: acute bacterial prostatitis, mostly caused by urinary tract infections, can cause frequent urination, urinary urgency, painful urination, perineum, suprapubic pain accompanied by pain and discomfort in the external genital area. 3. Epididymitis: In acute epididymitis, the scrotum on the affected side is swollen, and the scrotal skin is red, hot and painful, which can radiate along the lower abdomen and perineum. 4. Varicose vein of spermatic cord: abnormal elongation, dilatation and tortuous vein of spermatic cord, causing scrotal distension, vague pain and swelling, and the symptoms will be relieved by lying down. 5. Testicular tumor: the etiology is unclear, manifested as a mass in the scrotum on the affected side, with the increase of the mass, it can cause testicular heaviness, mild swelling or dull pain. Perineal pain and discomfort symptoms should be promptly to the hospital specialist, the doctor to clarify the cause of treatment.