Painful and itchy hands may be caused by herpes sweat, tinea cruris, atopic dermatitis and other factors. 1. Herpes sweat: the disease may be related to skin allergies, local infections and other factors, the patient’s hands may appear small blister-like lesions, slightly above the surface of the skin, with varying degrees of itching sensation, burning sensation, pain and other symptoms, usually recurring regularly every year. 2. Ringworm: The disease is mainly a superficial fungal infection caused by dermatophytes invading the skin of the hands. The patient’s hands may have blisters, scales, skin keratinization and other lesions, and may also have itching, pain and other symptoms. 3. Allergic dermatitis: the disease is mainly caused by contact with allergens, the patient’s hands may appear pimples, blisters, erythema, erosion and other lesions, and accompanied by itching, pain and other symptoms. It is recommended that patients go to the hospital in a timely manner to identify the cause of the disease and then carry out the relevant treatment.