Chronic kidney disease requires long-term treatment and management to avoid deterioration and progression to uremia. The treatment of chronic kidney disease includes the treatment of primary pathogenesis and causative factors, integrated treatment and so on. 1. Treatment of primary pathogenesis and causative factors: there are many causes of chronic kidney disease, so it is necessary to pay attention to the diagnosis and treatment of primary pathogenesis, and at the same time, it is necessary to actively search for various triggering factors for the aggravation of renal insufficiency, and to correct them reasonably. If there are hypertension and diabetes, patients can follow the doctor’s instructions to lower blood pressure and sugar. 2. Integrated treatment: including dietary treatment, treatment of complications (hypertension, anemia, water-electrolyte and acid-base balance disorder, infection, CKD-MBD, cardiovascular complications, etc.) and renal replacement therapy. Diet should pay attention to low salt and reasonable intake of protein; for the treatment of complications, ACEI/ARB drugs can be used for hypertension, specifically including chlosartan, valsartan, captopril, enalapril and so on; anemia can be given to human erythropoietin and other corrections of anemia and so on. It should be noted that chronic kidney disease is divided into 5 stages, each stage of treatment focus is different, 1 ~ 2 stage actively find the cause of the original disease, 3 stage should pay attention to the prevention and treatment of complications, 4 stage suggests that the patient every 3 ~ 6 months, including blood biochemistry and other tests, start to do a good job in preparation for renal replacement therapy; 5 stage of renal replacement therapy in a timely manner. In conclusion, chronic kidney disease requires individualized comprehensive treatment, and it is recommended that patients go to the hospital in time and receive standardized treatment under the guidance of specialists.