Wake up every morning mouth bitter if it is improper diet, poor hygiene habits and other physiological factors, generally do not need to take medication. If bile reflux gastritis, cholecystitis and other diseases, need to eat gastrointestinal dynamics for the cause of gastrointestinal drugs, gastric mucous membrane protective agents, choleretic drugs. 1. Physiological factors: eating greasy, stimulating food for a long time, or sleep eating bitter melon food, not timely cleaning the mouth, may lead to bitter mouth in the morning. This kind of situation is normal, no need to take drugs, but pay attention to change the lifestyle. 2. Periodontitis: periodontitis patients may also lead to bitter mouth in the morning, periodontitis requires systemic periodontal treatment such as cleaning, scraping, etc., while the local application of minocycline gel. 3. Bile Reflux Gastritis: Waking up every morning with a bitter mouth may also be caused by bile reflux gastritis, patients need to take oral gastrointestinal power drugs under the guidance of a doctor, such as domperidone, mosapride. Or oral gastric mucosal protective agents, such as bismuth potassium citrate, aluminum thiosulphate, magnesium aluminum carbonate and so on. 4. cholecystitis: every morning waking up with a bitter mouth is also considered to be due to cholecystitis, the patient can take oral choleretic drugs under the guidance of the doctor, such as magnesium sulfate, ursodeoxycholic acid. There are many reasons why patients wake up every morning with a bitter mouth, it is recommended that patients identify the cause of the disease in a timely manner, the use of drugs need to follow the doctor’s instructions.