Acyclovir may be tried for the treatment of monkeypox, but the medication should be used as prescribed by your doctor. Acyclovir is an antiviral medication that is used to treat herpes simplex virus, genital herpes virus, and shingles. Monkeypox is a zoonotic infectious disease caused by monkeypox virus infection. Once diagnosed with monkeypox mainly through symptomatic support mainly to control complications and prevent long-term sequelae. At present, there is no specific anti-monkeypox virus drugs, but can be tried for DNA virus drugs, such as acyclovir, vasiclovir, etc., but should be tried under the guidance of a doctor, not blindly self-medication. In the process of taking acyclovir, we also need to pay attention to, the people who are allergic to it need to be absolutely prohibited; dehydration or already have liver and kidney insufficiency patients need to be used with caution. After taking acyclovir there are also dizziness, headache, diarrhea, stomach upset, acne, insomnia, menstrual disorders and other adverse reactions, should be under the guidance of the doctor to use the drug properly.