Excessive hand sweating is clinically diagnosed as hyperhidrosis of the hands and feet and falls under the category of limited hyperhidrosis. Excessive excretion of sweat from the skin is known as hyperhidrosis, which can be caused by a variety of reasons and can be limited to a particular area or the whole body. Sweat gland activity is controlled by sympathetic nerves, mainly cholinergic fibers, emotional changes, internal and external temperature changes, drugs, diet, etc. can affect sweat secretion. Sweaty hands are more common, the patient’s hands are wet and cold is caused by exuberant secretion of the small sweat glands in the hands, often related to genetic factors, congenital constitution, mental stress, sympathetic excitation and so on. The sympathetic nerves innervating the sweat glands of the hands are too rich and sensitive, whenever mental tension, emotional excitement, the sympathetic nerves are often in a state of high excitement, the sweat glands also secrete a large amount of sweat, so the hands are prone to sweating. The patient’s sweaty hands can be persistent or transient, with wetness, coldness, or even cyanosis. As a result of sweat impregnation, localized whitening or peeling of skin, prone to fungal or bacterial infections. Treatment is mainly based on local treatment, first of all, attention should be paid to skin cleanliness, available formaldehyde solution topical application, formaldehyde solution, aluminum acetate solution, tannic acid solution soak hands or urotropin powder topical application, if there is secondary fungal infections to be antifungal treatment, dry cracked hands and feet should be externally moisturizing creams.