Survival of lung adenocarcinoma with targeted therapy is 2-3 years. Generally speaking, when distant metastasis or multiple metastasis occurs in the late stage of lung adenocarcinoma, if there is gene mutation in lung adenocarcinoma, targeted therapy can be carried out, and after 2 months of targeted therapy, lumps can be found, including primary foci and metastatic foci will be reduced to different degrees, and sometimes the lumps will disappear completely. After 8 months of treatment, there is a possibility of drug resistance, so we should pay attention to the rechecking in the course of treatment, and if drug resistance occurs, we should do genetic test again, and switch to different targeted drugs according to the result of gene mutation, and the survival period of the patients after treatment is 2-3 years.