Nine-valent HPV vaccine and quadrivalent vaccine target different HPV types and have different preventive effects. 1. Different types of HPV: The nine-valent vaccine targets HPV types 16, 18, 6, 11, 31, 33, 45, 52 and 58, while the quadrivalent vaccine targets HPV types 16, 18, 6 and 11. 2. Different preventive efficacy: the nine-valent vaccine can generally prevent 90% of cervical cancers, and the quadrivalent vaccine can basically prevent 70% of cervical cancers. The HPV vaccine has the best protective effect on women without a history of sexual life, and the preventive effect of the vaccine decreases with age. The two vaccines are suitable for vaccination at the age of 9 to 45 years old, and it is recommended that women in this age group be vaccinated as early as possible.