Cotrimoxazole tablets are a prescription medicine used for acute and chronic functional diarrhea and chronic enteritis. The drug contains diphenoxylate hydrochloride and atropine sulfate. The product can cause dependence when applied for a long time, but it is weaker than opioids and should be used with caution in patients with liver disease and those who are taking addictive drugs. Cotrimoxazole tablets are only advisable for short-term treatment with standing doses to avoid dependence. Adverse reactions include dry mouth, nausea, vomiting, headache, drowsiness, insomnia, rash, abdominal distension and intestinal obstruction, which disappear after dose reduction or discontinuation. This product is contraindicated in those who are allergic to this product and the ingredients contained therein, pregnant women, patients with severe ulcerative colitis with the possibility of developing toxic megacolon, patients with cirrhosis or jaundice due to the possibility of inducing hepatic encephalopathy. Nursing women should use with caution. Patients who need to use the drug, it is recommended to use it under the guidance of a professional doctor.