Newlywed erectile dysfunction, referred to as “honeymoon impotence”, refers to erectile dysfunction that occurs when a young man who is married or unmarried has lived together for the first time since marriage or cohabitation, especially in the first few times of sex; it causes great negative impact on the patient and his partner and family, and if it does not get a timely and effective solution. will cause serious impact on the couple’s relationship and the stability of the family after marriage. Newlywed erectile dysfunction has a high prevalence in the conservative East Asian region, and the literature reports that it accounts for about 17%-22% of erectile dysfunction, especially in our male outpatient clinics is gradually increasing trend, is a more common type of male erectile dysfunction in particular. Patients usually have no experience of intercourse before marriage or cohabitation, or only experience failure. Most of the patients will choose to go to the hospital after a few failed attempts at intercourse, but a small number of patients will have symptoms for a long time, such as half a year or a few years before they go to the hospital, and even some patients only go to the hospital after marriage when they are considering having children, and only through detailed questioning of their sexual history is the existence of serious sexual dysfunction discovered. Lack of sexual experience and behavioral anxiety are considered to be the main causes. The reasons include anxiety and fear of the upcoming sexual life of both men and women, lack of sexual knowledge and skills, misconceptions and unrealistic ideas about sexual life, etc. In the clinic, it is found that most patients generally lack the most basic sexual knowledge, lack basic understanding of the sexual organs and sexual response cycle of both men and women, especially the female, so that there are many wrong perceptions and ideas about sexual life, such as thinking that sexual stimulation is not needed during coitus, or being influenced by some unrealistic and exaggerated yellow obscene propaganda, having too high expectations of sexual life, lack of necessary emotional communication and physical contact during sexual life This is the main reason for the failure of sexual intercourse. The main way to solve this problem is the popularization of sexual knowledge and the strengthening of premarital sex education, which can be achieved through the popularization of basic sex education, the intervention of social media, the participation of professionals and the establishment of patient help lines. Most parents are shy and avoid discussing sex-related topics with their children, and unmarried young people get their sexual knowledge mainly from informal magazines, some satellite programs, peers or married siblings, etc., which are mixed with many exaggerated and unrealistic contents. Newly married erectile dysfunction occurs mainly in young or middle-aged adults, most of whom have good morning erections or penile erections with sexual stimulation, and whose past medical histories all exclude ED-related risk factors such as hypertensive disease, diabetes, and hypogonadism, considering psychological factors as one of their main etiologies. We use the form of pictures, detailed sexual knowledge and sexual skills guidance to the affected couple, such as the anatomy and physiological function of male and female organs, the characteristics and differences of male and female response cycles, the avoidance of unfavorable timing during sex, adequate emotional communication and physical contact before intercourse; at the same time, it is necessary to let patients realize that not all sex is satisfactory, and occasional failures are inevitable and do not mean the occurrence of disease. does not mean the occurrence of disease. Newlywed erectile dysfunction causes great distress to both men and women, especially the male partner, and the initial failure of coitus makes men suffer from internal guilt and torment, from the reproach of sexual partners, family discrimination, and even many well-intentioned help will increase their internal guilt. In the past, it was widely believed that sexual ability is an innate human function and sexual knowledge can be acquired through gradual accumulation after marriage; however, in the process of in-depth contact with primary ED patients, it was found that although most people’s anatomy and physiological functions are completely normal, at least for some newlywed men, their ability to have sex is not innate and needs to be learned with the help of doctors or professionals. Some are even deterministic. Oral PDE5 inhibitors have been shown to be safe and effective in the treatment of erectile dysfunction, including sildenafil (Viagra), tadalafil (Cialis), and vardenafil (Elidel), and PDE5 inhibitors can significantly improve the number, hardness, and duration of erections in patients with psychogenic ED, increase mutual satisfaction with sex, and help break the vicious cycle of behavioral anxiety and failure. failure, resulting in a long-lasting recovery of erectile function. The majority of newlywed erectile dysfunction is mainly moderate to severe ED, most of which manifests as the inability to get an erection during intercourse or to obtain sufficient hardness to complete penetration. The successful sexual life caused by the initial application of PDE5 inhibitor obviously enhanced the confidence of the patients, improved the sexual satisfaction of both spouses, and built a good relationship between the spouses; on this basis, the training of sexual skills was carried out, and the ability of natural erection was gradually restored. On the basis of the gradual recovery of natural erectile function, the dependence on drugs was gradually removed, which may be the mechanism for the good efficacy of PDE5 inhibitor treatment. Newlywed erectile dysfunction has a high incidence and is a common disorder plaguing newlywed couples, seriously affecting the physical and mental health of patients and their spouses and the stability of the family, requiring social support, attention from mainstream media and the attention of professionals. The popularization of sexual knowledge and the reinforcement of sexual education are the basis for the prevention and treatment of primary ED; psychological factors mainly cause patients’ lack of self-confidence, worry and anxiety about erection and the reduction of spontaneous erection, while for most newlywed patients with erectile dysfunction, the restoration of voluntary erection and sex without relying on drugs are their ideal goals. PDE5 inhibitors have been found to be safe and effective in the treatment of newlywed erectile dysfunction, and most patients can be completely free from erectile dysfunction and restore normal erectile function or even “cure”, but a planned, course of behavioral and pharmacological treatment is required, and individualized treatment protocols are used depending on the etiology, age, and severity of erectile dysfunction. The treatment plan is individualized according to the cause, age and severity of erectile dysfunction.