Azithromycin is effective in treating sinusitis caused by bacterial infection. However, if there are allergies or nasal structure abnormalities, etc., it is necessary to treat the cause of the disease, and symptomatic treatment is also needed for those with obvious symptoms. Azithromycin belongs to the macrolide class of drugs, the drug can not only be used for the treatment of acute sinusitis caused by sensitive bacterial infection, chronic sinusitis can also be standardized under the guidance of a physician to use azithromycin for treatment. Chronic sinusitis diagnosis and treatment guidelines indicate that macrolides have anti-inflammatory, immunomodulatory and antibacterial effects, clinical studies have shown that the effectiveness of macrolides in the treatment of chronic rhinosinusitis is 62.0% to 92.1%, in the clinic recommended small doses of long-term oral macrolides, so azithromycin is effective for chronic rhinosinusitis. Azithromycin use may cause some drug side effects such as nausea, vomiting, diarrhea, abdominal pain, and rash. Also people who are allergic to azithromycin or other macrolide antibiotics need to disable the drug. Individuals who experience any signs of an allergic reaction to the medication should stop using it immediately and seek professional medical help. Sinusitis patients should not abuse azithromycin or other antibiotics on their own, and the medication should be prescribed by a doctor to be reasonable and scientific.