High adrenal stimulating hormone can be vaccinated against rabies. Because rabies is a fatal disease, post-exposure rabies vaccination is required in the event of a bite or scratch from a dog or cat. During the process of rabies vaccination or use of passive immunization preparations, the vaccinee should be fully questioned about his/her basic individual condition, such as whether he/she has a history of severe allergies, and other serious illnesses. Vaccination should be administered under close supervision, even if there are circumstances that make vaccination inappropriate. Although adrenotropic hormone may affect the effectiveness of rabies vaccination to some extent, it is still necessary to administer the vaccine in a timely manner after suspected exposure has been determined. Therefore, people with high adrenal stimulating hormones can be vaccinated with rabies vaccine, but they need to be screened for antibody titers to ensure the effectiveness of the vaccination.