Bone tumor originates from mesenchymal cells, under the action of many different extrinsic and intrinsic factors, it triggers a class of benign and malignant tumors of bone tissue itself and other structures attached to the bone, such as osteogenic, cartilaginous, fibrous tissue-derived, giant cell tumor of bone, adipose and so on. Malignant bone tumors may originate in bone or metastasize to bone from other places, and may invade and destroy surrounding tissues and organs or metastasize to distant places. Benign tumors can also cause damage depending on their location and size, and can be harmful to human health. Why are bone tumors a dangerous tumor? People lack of understanding of bone tumor, early clinical symptoms of patients fail to attract attention, often misdiagnosed as injury, infection or arthritis, etc. 60% of patients with malignant bone tumors are already in the middle or late stage when they consult the doctor, 50% of patients delayed due to failure to get timely diagnosis and standardized treatment, and when the diagnosis is confirmed, the tumor is often very large, surgical resection is difficult, or metastasis has already occurred, and they are faced with the risk of forced amputation due to postoperative local recurrence or life-threatening distant metastasis. They face the double threat of amputation due to postoperative local recurrence or life-threatening distant metastasis. How to detect bone tumor at early stage? Pain and limb swelling are the main symptoms of bone tumor. At the early stage of development, patients often have irregular hidden pain and discomfort in the limbs, which is not related to movement, and it is intermittent at the beginning, and then develops into persistent and obvious at night; meanwhile, limb swelling and lumps gradually appear. Benign mass grows slowly, malignant bone tumor grows rapidly, varicose veins of the skin on the surface of the tumor, increased skin temperature, and there may be joint swelling and activity disorder. Tumors in the pelvis or sacrum are not easy to detect in the early stage, but there is pain and numbness in the perineum, constipation and urinary disorders. When patients have the above symptoms, which tend to worsen, they should go to the bone tumor specialist of each hospital in time. How to diagnose and treat bone tumor? The diagnosis and treatment of bone tumor include clinical, imaging and pathology diagnosis, radiotherapy and chemotherapy, and comprehensive treatment mainly based on limb preserving surgery, etc. The first step is to establish the diagnosis through puncture biopsy. The first step is to establish the diagnosis through puncture biopsy. If the scope is limited, the tumor can be removed by surgery; usually, chemotherapy and radiotherapy should be combined before and after surgery to reduce recurrence and metastasis. Puncture biopsy The classification and diagnosis of bone tumors are extremely complicated, and it is very difficult to make a correct diagnosis simply by relying on clinical examination and imaging, and biopsy is the necessary way to diagnose most of the bone tumors. Biopsy is a necessary way to diagnose most bone tumors. Biopsy is divided into puncture biopsy and incision biopsy. Puncture biopsy is the use of coarse cannula needle to puncture the patient’s diseased bone tissue, with the advantages of low cost, small trauma, fast recovery, etc., and chemotherapeutic drugs can be applied on the second day after the puncture. Incisional biopsy is often performed after a failed puncture biopsy, with an incision of about 6-200px, which is traumatic and slower to recover. After some hospitals carry out incision biopsy, it brings difficulties to the limb preservation surgery of the second extensive resection of the tumor, which makes the patients lose the opportunity of limb preservation. Bone tumors are complex in origin and diverse in type, and it is difficult to make a clear diagnosis simply by clinical, imaging or pathology, and the misdiagnosis rate is high. Therefore, the combination of clinical, imaging and pathology is the best way to diagnose bone tumor, which is recognized at home and abroad and proved by practice. Neoadjuvant chemotherapy Chemotherapy is one of the important means to treat malignant bone tumors by killing tumor cells in the body with drugs, which greatly improves the prognosis of patients. The application of neoadjuvant chemotherapy (preoperative chemotherapy) makes the possibility and success rate of limb-preserving reconstruction surgery for malignant bone tumors increase greatly, and it can be said that chemotherapy is the cornerstone of successful treatment of malignant bone tumors. New technology of chemotherapy care PICC is a catheter placed into the central vein through peripheral vein puncture at the elbow. It can effectively protect the patient’s peripheral blood vessels, reduce the pain of repeated puncture, reduce phlebitis and venous sclerosis, and reduce the risk of chemotherapeutic drug leakage and necrosis of the surrounding tissues. The catheter is easy to maintain, and can be left in place for a long time throughout the treatment process, and can be used for a variety of intravenous treatments such as infusion, transfusion, blood sampling, etc., which improves the quality of patient’s survival, and is the first choice of intravenous treatment channel for chemotherapy patients. Misconceptions in diagnosis and treatment such as “minor surgery” or incisional biopsy when the diagnosis is not clear, so that the patient loses the chance of limb-saving surgery and long-term survival. Informal chemotherapy is more likely to induce chemotherapy resistance, delaying the best time for treatment and leading to treatment failure. Appropriate application of traditional Chinese medicine for adjuvant treatment after surgery can regulate blood and qi and enhance immune function, etc. However, if we hope to rely solely on external application of local traditional Chinese medicine and internal intake of traditional Chinese medicine as a “cure-all” means, we can only delay the time of treatment, and ultimately, lung metastasis will occur and death will be caused. The earlier the sarcoma is detected, the higher the cure rate is, and standardized comprehensive treatment is the key to cure sarcoma. The standardized comprehensive treatment is the key to the cure of sarcoma. The first diagnosis and first treatment are directly related to whether the patients can retain the function of limbs, and the best time for treatment is the first surgery. The best time for treatment is the first surgery. Adopting the comprehensive individualized treatment plan mainly based on surgery, combined with radiotherapy and chemotherapy, so that the patient can get curative treatment.