High thyroid stimulating hormone is generally acceptable for painless gastroscopy in the absence of contraindications, and it is recommended that you consult your doctor. High thyroid stimulating hormone can be seen in hypothyroidism, subclinical hypothyroidism, and hyperpituitary hyperthyroidism. Simple high thyroid stimulating hormone without arrhythmia or cardiac involvement is not a contraindication to painless gastroscopy, and painless gastroscopy can be performed. Contraindications for painless gastroscopy include severe heart disease, such as myocardial injury, cardiac insufficiency, coronary artery disease, etc.; uncontrolled blood pressure; acute asthma attack, pulmonary infection, acute respiratory tract infection; extreme weakness, hemorrhagic shock, cardia obstruction, esophageal stenosis, severe liver and kidney diseases, etc. Whether painless gastroscopy can be done should be decided after a specialized physician evaluates the patient’s condition.