The most common causes of knee squatting pain are chronic knee strain, ligament injury, meniscus tear, osteoarthritis, patellofemoral arthritis, chondromalacia patellae, etc. If the symptoms persist, it is recommended to consult a doctor in time. 1. Chronic knee strain: if long-term sports activities, it is easy to cause chronic injury to the quadriceps muscle, and then the knee pain in squatting, it is recommended to wear sports knee pads. 2. Ligament injury: ligament injury or rupture around the knee, such as patellar ligament strain, may cause knee pain when squatting. 3. Meniscus tear: strenuous exercise may cause meniscus tear, resulting in squatting pain, the need for timely icing, if necessary, minimally invasive arthroscopic meniscus surgery to repair. 4. Osteoarthritis: the bones of the knee joint will degenerate with age, there may be osteophytes that irritate the surrounding soft tissue causing pain. Symptoms of knee squatting pain may occur. 5. Patellofemoral arthritis: when there is friction between the patella and the femur, repeated wear and tear may cause inflammation, and then pain in squatting. 6. Chondromalacia patella: due to the femur and patella joint surface damage, and then appear the knee joint pain, and in the beginning of the activity pain is more obvious, squatting can also cause knee pain. Causes of knee pain squatting more causes, if the rest does not relieve, it is recommended to promptly go to the hospital to identify the cause of the disease, the doctor targeted treatment.