Creatinine 250μmol/L first need to clarify the cause of the disease, divided into acute renal failure and chronic renal failure, need to treat the cause, can be given to protect the kidneys and lower creatinine drugs as well as correction of acid potassium and other symptomatic treatment, low-salt, low-fat, low-protein diet and other treatments. 1. Acute renal failure: acute causes of renal failure, such as drugs, obstruction and other factors, follow the doctor’s instructions for the cause of the systematic treatment, such as stopping the use of suspected drugs, relief of obstruction and so on, most of them can be cured. 2. Chronic renal failure: caused by chronic glomerulonephritis, diabetic nephropathy and so on, belongs to chronic kidney disease. Creatinine 250μmol/L, can only maintain the condition through drugs, and there is a risk of progression to uremia in the future. Oral kidney protection and creatinine-lowering medications, such as urethane granules and kidney capsules, can be taken as prescribed by the doctor. In addition, patients with elevated creatinine are often accompanied by kidney damage, elevated blood pressure, etc., and need a low-salt, low-fat diet and blood pressure adjustment. It is recommended that patients with elevated creatinine go to the hospital in time, under the guidance of the doctor to clarify the cause of the disease, standardized treatment.