The prognosis of patients with advanced liver cancer combined with metastasis is poor, and the specific survival period varies from person to person, with some studies claiming that their average survival time is only about 13 months. Patients with advanced hepatocellular carcinoma are usually in serious condition, and may be combined with obvious anemia, hypoproteinemia, malignant ascites, progressive decline of liver function, etc. Moreover, metastasis, such as intrahepatic metastasis, lymph node metastasis, distant metastasis, etc., usually exists; in addition, some of the patients may suffer from spontaneous peritonitis, which may induce hepatic encephalopathy. Cancer prognosis is generally assessed by survival rate, and liver cancer prognosis is related to disease progression (e.g., stage, etc.), therapeutic program, patient’s basic condition, etc. The prognosis of advanced liver cancer is generally poor. Some domestic studies claim that the 1-year survival rate of advanced liver cancer is only about 20%; other studies claim that the average survival time of patients with liver cancer combined with distant metastasis is about 13 months. However, the exact time varies from person to person and there is no definite conclusion yet. It is recommended that patients diagnosed with advanced liver cancer should go to regular hospitals to evaluate their conditions and follow the doctor’s instructions to cooperate with the treatment, so as to control the progression of the disease and improve the prognosis of the patients.