When ventricular fibrillation occurs after surgery for myocardial infarction with three-vessel occlusion, electric defibrillation should be given first, and drugs should be given for treatment if necessary. 1. Defibrillation: ventricular fibrillation after three-vessel occlusion surgery for myocardial infarction is a common critical illness in clinic, and the mortality rate is very high, at this time, we should immediately give defibrillation treatment, and can give defibrillation several times, and at the same time, intravenous drugs are given for treatment. 2. Give medication: when ventricular fibrillation occurs, intravenous infusion of amiodarone or esmolol can be used to correct rhythm disorders, and atropine or epinephrine can be given to patients with ventricular fibrillation for rescue. Ventricular fibrillation is a kind of fatal arrhythmia, must be actively defibrillation treatment, in the cardiovascular department for active rescue.