Patients with Parkinson’s disease experience motor symptoms such as uncontrollable tremors in the hands and feet, stiffness in the limbs, and difficulty in starting movement due to a dramatic degeneration of the substantia nigra in the brainstem that prevents the production of a neurotransmitter called dopamine, resulting in a decrease in the brain’s ability to direct muscle activity. However, the presence of motor symptoms such as tremors in the hands and feet means that the patient has entered the clinical phase. Before that, the patient will have non-motor symptoms such as loss of smell, depression, and constipation. Most people think that hand tremor is a symptom of Parkinson’s disease, followed by rigidity. Non-motor symptoms (insomnia, depression, joint pain, etc.) are often ignored, and patients are often seen in psychiatric and orthopedic clinics at the beginning of the disease, and only realize the possibility of Parkinson’s disease when rigidity and tremor symptoms appear again as the disease progresses, but in fact, Parkinson’s disease has been latent for many years. In addition to motor symptoms, Parkinson’s disease patients often also exhibit a variety of non-motor symptoms such as depression, anxiety, early mild cognitive impairment, late dementia, psychotic symptoms, sleep disorders, sensory abnormalities and urinary and bowel disorders, smell disorders, chest tightness and gas, and abnormal sweating. Sleep disorders. Sleep disorders are a common non-motor symptom of Parkinson’s disease, with an incidence of more than 50%. Common sleep disorders include insomnia, excessive daytime sleepiness, abnormal behavior during fast-acting eye sleep, sleep apnea, restless legs syndrome, etc. Depressive disorders. Less speech, less movement, depressed mood, decreased interest, early awakening, feelings of fatigue, and anxiety …… Patients with Parkinson’s disease also experience these depressive manifestations. According to statistics, the prevalence of depressive disorders in patients with Parkinson’s disease is more than 40%. Cognitive dysfunction. According to statistics, 22% to 48% of patients with Parkinson’s disease present with altered cognitive function and dementia, and mild cognitive impairment is already present early in the onset of Parkinson’s disease. As the disease progresses, there is a tendency for cognitive impairment to gradually worsen in Parkinson’s disease patients. It has been reported abroad that about 52% of patients develop dementia after 4 years of onset, while nearly 80% of patients will develop dementia after 8 years. Therefore, many people will mistake Parkinson’s cognitive dysfunction for dementia. Language dysfunction. The main manifestations are varying degrees of pharyngeal articulation and tongue movement disorders, with diminished vocalization being the first manifestation. In addition, there is single pitch, slowed speech, abnormal speech pauses, sustained vocalization disorders, abnormal stress, speech slurring and hoarseness, decreased fluency of spoken expression, and simplification of syntactic expression. Many patients with Parkinson’s disease have non-motor symptoms, but because they are not representative, they are often easily overlooked and treatment is delayed by visits to other departments.