If the pain in the liver area persists for half a year, the patient is usually considered to have vague discomfort in the right upper abdomen and the back, or the possibility of distension and discomfort. At this time, it is recommended to further check the ultrasound of the upper abdomen to see whether the patient’s liver is enlarged or atrophied, and whether the patient may have hypoechoic or hyperechoic swelling in the liver area. For some patients, a blood test for alpha-fetoprotein is also required to see if the patient has elevated alpha-fetoprotein. If there is a combination of elevated AFP and a history of chronic viral hepatitis B or C, an enhanced CT or ultrasonography of the upper abdomen will be considered to determine the possibility of primary liver tumors. If there is hypoechoic mass and the patient is diagnosed as primary tumor of liver by enhanced CT or MRI, radiofrequency ablation surgery or surgical resection should be considered as soon as possible, and the patient needs further observation and review after surgery.