Small blisters, or blisters, on the mouth are often due to herpes simplex virus infection. Lancing is usually not recommended and may increase the risk of infection. Small blisters on the mouth may be associated with a herpes simplex virus infection, where there is more fluid in the blisters and the walls of the blisters are tense, making them susceptible to rupture when rubbed or touched. If the blisters are not well taken care of after rupture, it may lead to fluid oozing, erosion or secondary infection, which will easily increase the difficulty of treatment. After a certain course of antiviral treatment it will scab over and be absorbed. However, if the blisters are broken, it is recommended to use anti-infective medications such as mupirocin ointment and fusidic acid cream under doctor’s supervision to reduce the chance of infection. It is recommended that blisters on the mouth should be treated promptly and in accordance with the doctor’s instructions, and avoid squeezing and puncturing them on your own.