The best treatment option for early stage of chronic leukemia is targeted drug therapy, such as imatinib. The early stage of chronic leukemia is characterized by splenomegaly, which may be accompanied by fever, malaise, anorexia, weight loss and other symptoms. Early main treatment is based on targeted drug therapy, targeted therapy drugs such as imatinib, erlotinib, dasatinib and so on. Targeted therapy is suitable for patients in the chronic stage and is currently recommended by international guidelines as the main treatment option. It has good efficacy, good safety, is easily tolerated by patients, does not affect the quality of life, and has a long median survival time. Some patients will develop drug resistance after taking the drug, resulting in disease progression. Hematopoietic stem cell transplantation, use of interferon and chemotherapeutic drugs can be performed for a small number of treatment failures. Chronic granulocytic leukemia is recommended to be treated under the guidance of a specialist, and blind self-medication should be avoided.