Baby colic and intussusception are two different pathological conditions, which can be judged from clinical manifestations, auxiliary examinations and other aspects. 1. Clinical manifestations: colic is a kind of functional abdominal pain, the baby with colic can have obvious crying, longer duration, and not easy to appease, more common at night, during the period of time, there can be a red face, clenched fists or legs curled up and other manifestations. And intussusception for organic lesions, in addition to paroxysmal crying, can be accompanied by vomiting, decoction of jam-like stools, some babies can also appear depressed, examination can touch the abdominal mass and so on. 2. auxiliary examination: for colic baby general perfect abdominal ultrasound basically normal, basically no obvious abnormal changes. And the baby of intussusception line abdominal ultrasound can be seen in the disease-specific changes, such as “concentric circles” or “target ring”, etc., line abdominal X-ray can be seen in the gas-liquid equal intestinal obstruction changes. It is recommended that babies with abdominal discomfort be actively consulted and evaluated by a specialist.