A big pimple hard, may be folliculitis, sebaceous cysts, scabies, etc., can be in a clear cause for targeted treatment. 1. Folliculitis: this disease is a hair follicle-based inflammatory skin disease, the onset of the patient’s skin can lead to large pimples and hard, mild patients can be self-healing, serious cases can be prescribed the use of fusidic acid cream, mupirocin ointment, amoxicillin capsules and other drugs. 2. sebaceous cysts: this disease is related to the patient’s skin sebaceous gland duct blockage, long-term chronic course, treatment based on surgical excision, infection can be prescribed local use of erythromycin ointment or oral use of amoxicillin capsules and other medications to control inflammation, in the inflammation subsides after surgical excision treatment. 3. Scabies: This disease is mainly related to Staphylococcus aureus infection, usually one or more red, hemispherical painful nodules. It can cause the patient’s skin to appear hard and large pimples, often accompanied by pain. If the symptoms are obvious, the patient can be treated with medications such as ichthyol ointment and mupirocin ointment, and if the boil breaks down with pus, incision and drainage will be required. When the skin appears hard big pimples, we should pay attention to avoid squeezing with hands, if the symptoms are obvious or gradually aggravated, the patient should go to the regular medical institutions in a timely manner, in accordance with the recommendations of the specialist physician standardized treatment.