Patients who themselves experience an exacerbation of eczema after a mild eczema vaccination usually have an exacerbated reaction because their body’s immunity is lower after the vaccination. Therefore, vaccination is not recommended when eczema flares up. Vaccination is a foreign stimulus to the body, equivalent to a mild infection. Dead vaccines and dead vaccines are a foreign stimulus to the body, and while producing immunity after vaccination, they may produce local or systemic reactions of varying degrees, or aggravate pre-existing diseases. Vaccines usually contain foreign proteins that form good antigens and stimulate the organism, and a mild allergic reaction may occur after entering the body by injection. If mild eczema is already present, the protein component of the vaccine may cause the eczema symptoms to worsen. It is usually advisable to avoid vaccination during eczema flare-ups and to postpone vaccination until the eczema has healed. In special cases where vaccination is given during an eczema flare-up, it is necessary to closely observe changes in eczema lesion symptoms after vaccination. If eczema suddenly worsens or itching increases, topical application of drugs such as glyburide lotion, glucocorticoid cream or gel can be used, and antibiotics can be added to prevent secondary infection. Severe symptoms require prompt medical attention and no self-administered medications. Some vaccines are not suitable for eczema patients, such as BCG vaccine, which is not recommended for people with tuberculosis, acute infectious diseases, heart, kidney and brain diseases, extreme malnutrition, eczema and other skin diseases, and HIV infection. Patients with eczema should consult a physician to understand contraindications to vaccination.