Gallbladder cancer without combined metastasis has the possibility of clinical cure, but still has the possibility of recurrence or metastasis. Gallbladder cancer refers to malignant tumors occurring in the gallbladder (including the base, body, neck and ducts of the gallbladder), and is one of the common malignant tumors in the biliary system. Radical resection is the most effective treatment to improve the prognosis of patients. There are many factors affecting its prognosis, which are related to the stage of the disease, the patient’s own condition (age, physical ability, etc.), and treatment. The prognosis of patients with gallbladder cancer not combined with metastasis needs to be judged according to the specific stage. If it is only limited gallbladder tumor, radical cholecystectomy can be given, and regular review is usually enough after surgery, and some patients can achieve clinical cure, and some studies say that their 5-year survival rate is above 70%; If gallbladder cancer invades surrounding tissues/organs (e.g. liver, gastroduodenum, colon, pancreas, extrahepatic bile ducts, etc.), radical surgery combined with resection of peripheral tissues/organs is needed, and postoperative adjuvant treatment is needed according to the situation, and some studies claimed that its 5-year survival rate is less than 40%. If gallbladder cancer is suspected or diagnosed, it is recommended to go to regular hospitals to evaluate the condition, follow the doctor’s instructions to cooperate with the treatment, and choose the appropriate treatment plan to improve the quality of life and prolong the survival period.