Polycystic generally refers to polycystic ovary syndrome, which can lead to metabolic abnormalities associated with insulin resistance, which can cause increased blood glucose, so polycystic ovary syndrome can be treated with metformin if insulin resistance is present. Metformin reduces insulin resistance by increasing glucose uptake and reducing hepatic glucose production. The main side effect of metformin is gastrointestinal reactions, which can be reduced by taking the medication with meals, starting with a small dose and gradually increasing the dose; some patients may also experience other adverse reactions, which are subject to individual variability. Patients with a confirmed diagnosis of polycystic ovary syndrome and normal insulin levels are advised to go to the hospital and ask their doctor to determine whether they need to be treated with metformin in the light of their condition.