Blisters on the corners of the mouth are relatively common in daily life. Blisters on the corners of the mouth may be caused by fire, or they may be caused by herpes virus infection. The treatment of blisters on the mouth is mainly through the following options: 1, virus-induced herpes simplex: antiviral treatment is needed, such as acyclovir cream, interferon gel local application, you can also take oral acyclovir capsules, famciclovir capsules. 2, fire: can be treated with local antibiotic cream, such as erythromycin ointment, gentamycin cream, pay attention to a light diet, drink more water, you can also apply 3, physical therapy: laser treatment for the treatment of corner of the mouth blisters has a very good effect, especially infrared can be anti-inflammatory, itching, pain.