A pimple on the penis, if it does not affect the patient’s work and life, may be related to factors such as the patient’s underwear being too tight and rubbing against the penis, or frequent sweating in summer when it is too hot. In milder cases, the symptoms may subside on their own within a short period of time and no special treatment is needed. In addition, it may also be related to pathological factors and may be treated accordingly: 1. Folliculitis: purulent infection of the hair follicles, which may be related to factors such as summer heat, body sweating, hair friction, and poor local hygiene, resulting in the invasion of skin tissue by germs. Patients may have red follicular papules on the penis, which may later turn into corn-like pustules, which may be surrounded by a red halo, shaped like a pimple. Local cleanliness and hygiene should usually be maintained, avoiding friction and squeezing, and topical ointments, such as mupirocin ointment, should be used. If patients have local fever, pain and other symptoms, they can also choose suitable antibiotics for treatment under the guidance of a doctor; 2, sebaceous cysts: that is, sebaceous secretions in the subcutaneous stagnation, resulting in the penis area acne-like symptoms of blackhead acne and cyst infection, which can occur singly. The main clinical treatments are laser, liquid nitrogen freezing, and surgical excision. In addition, a pimple on the penis may also be a manifestation of penile dermatofibroma, syphilis, eczema, genital herpes and other diseases, therefore, it is recommended that patients should actively go to the hospital for consultation and treatment when the above symptoms appear, so as not to delay the disease and treatment.