Malassezia is a resident fungus in human hair follicles, and its infection type is generally divided into superficial sebaceous layer and hair follicle infections, which can be treated with antifungal therapy according to individual conditions and the doctor’s diagnosis. Superficial site infections are usually manifested as lichen planus, and commonly used creams include ketoconazole lotion, miconazole cream, and tincture of bifidazole cream. Certain herbal medicines are also effective in treating superficial areas of infection, such as Xionghuang Detoxification San plus Bai Biao Wine, or Tu Geun Pi, Clove plus alcohol topical rubs can significantly improve the symptoms of lichen planus. Hair follicle infection generally manifests as Malassezia folliculitis, which requires the use of ointments with higher permeability and poorer general antifungal treatment. Drugs commonly used clinically include amphotericin B, flucytosine, itraconazole, and fluconazole. Oral itraconazole capsules etc. can be used for severe symptoms. Malassezia infection occurs and can usually be treated with a combination of drugs. However, the disease is prone to recurrence after the infection is cured. It is necessary to pay attention to personal hygiene, bathe, change clothes and dry bedding regularly to keep the skin clean and dry and reduce the secretion of oil and grease to reduce the chance of recurrence of Malassezia infection.