Wake up in the middle of the night anterior heart pain, coronary ct without abnormalities can not indicate that there is no problem, should also consider variant angina and duodenal ulcer and other diseases. 1. variant angina: relatively rare, generally caused by coronary artery spasm, coronary artery without organic lesions, so the coronary ct may not be able to see, its symptoms and other angina pectoris is different, variant angina pectoris often occurs at rest, the night is more common, the onset of time is longer than other angina pectoris, onset of the electrocardiogram st-segment elevation, often accompanied by symptoms of sweating. 2. Duodenal ulcer: due to the weakening of the duodenal mucosa, stomach acid corrosion caused by the pain often occurs in hunger or at night, the patient will often mistake the location of the pain for the heart, so the heart examination is not abnormal, and ignore the gastrointestinal diseases. It is recommended that patients go to the local regular hospital, complete the relevant examinations under the guidance of the doctor, and follow the doctor’s instructions for treatment.