Itching on both sides of the thighs with small pimples is mainly due to insect bite dermatitis, eczema and other causes, can be used under the guidance of the doctor oral medication, applying drugs and other methods of treatment. 1. Insect bite dermatitis: mainly caused by insect bites, the lesions will lead to allergic reactions, manifested as itching on both sides of the thighs with small pimples. It can be treated with local application of glycerite lotion and mometasone furoate cream. 2. Eczema: Allergy is an important cause of eczema, and allergens can come from outside or inside the body. Eczema can appear on both sides of the thighs itching with small pimples. You can use topical glucocorticoid drugs, oral loratadine tablets, chlorpheniramine maleate tablets and other drugs to treat it. Itching on both sides of the thighs with small pimples may also be the cause of chickenpox, need to make targeted treatment under the guidance of the doctor. All of the above drugs should be used under the guidance of a doctor.