Drinking alcohol after taking azithromycin is not recommended, because azithromycin is a macrolide antibiotic, the side effect is that it may cause liver damage, and drinking alcohol afterwards will increase the burden on the liver and cause increased liver damage. However, Azithromycin and alcohol do not produce disulfiram-like reaction, which is a reaction between cephalosporin antibiotics and nitroimidazole antibiotics such as metronidazole and ornidazole and alcohol, and patients will have serious symptoms such as flushing, nausea, vomiting, palpitation, chest tightness, shortness of breath, or even hypotension and shock when disulfiram-like reaction occurs. Alcohol should not be consumed after application, but azithromycin may aggravate liver damage, so alcohol consumption is also not recommended.