The symptoms of itching, peeling, dryness and hardness of the scrotum may be caused by a variety of reasons, including scrotal infection, scrotal eczema and scrotal dermatitis. It is recommended to visit the hospital in time to clarify the cause and carry out targeted treatment to avoid aggravation of the symptoms. 1. scrotal infection: if the patient has bacterial infection or fungal infection in the scrotal area, it can be manifested as scrotal itching, peeling skin, dry cracking and hardening. Patients need to pay attention to keep the scrotal skin clean and apply topical anti-infective drugs such as fusidic acid ointment to help relieve the symptoms. In addition, according to the different types of infection can also be combined with oral cephalosporin, ketoconazole, mycobacterium and other drugs for treatment; 2, scrotal eczema: patients with scrotal itching, peeling, dry cracking, hard symptoms, consistent with the performance of the chronic phase of scrotal eczema, usually accompanied by infiltrative thickening, moss-like changes and other symptoms. The causes are usually related to abnormal immune function, systemic diseases, and external factors such as poor living habits and environmental stimuli. Glucocorticoids such as hydrocortisone butyrate ointment and fluocortisone ointment, combined with antihistamines such as benadryl and loratadine, can be used topically under the guidance of a professional doctor to help relieve itching and reduce inflammation quickly. In addition, the use of immunosuppressants, antibiotics and other drugs, or the choice of ultraviolet light therapy and other ways to help relieve symptoms; 3, scrotal dermatitis: If the patient has scrotal dermatitis, the main manifestation of local skin mossy lesions, accompanied by intense itching, can appear scrotal itching, peeling, dry, cracked, hard symptoms, the cause of the onset of endocrine disorders, gastrointestinal dysfunction and mental The causes are related to endocrine disorders, gastrointestinal dysfunction and mental factors. It can be treated with antihistamines, sedatives and sleeping pills, and corticosteroid ointments such as hydrocortisone butyrate and mometasone furoate according to the specific degree of dryness and hypertrophy of the scrotum. Other modalities such as superficial X-ray radiation therapy and cryotherapy are also available for treatment.