Scabies is caused by infection with the scabies mite, scrotal scabies nodules are a kind of reddish-brown, soy-like size nodules that occur in the scrotal area, and clinical treatment is mainly based on medication, and if necessary, physical therapy such as liquid nitrogen freezing therapy and carbon dioxide laser therapy can be used to strengthen the therapeutic effect, and nodules can also be surgically removed if they are serious. Treatment methods are more, it is recommended that patients combine their own will and doctor’s guidance to choose a comprehensive: 1, drug therapy: clinically used drugs to kill scabies mites mainly include clomid ointment, sodium thiosulfate solution, dilute hydrochloric acid solution, etc. Patients with severe itching can use sulfur ointment to stop itching. In addition, patients with scrotal scabies nodules can also be treated with external application of coal tar gel and local injection of glucocorticoids such as trimethoprim; 2, physical therapy: physical therapy methods such as liquid nitrogen freezing therapy and carbon dioxide laser therapy can selectively destroy the tissue in which scrotal scabies nodules occur, and thus can achieve the purpose of treatment; 3, surgical treatment: mainly applies to patients for whom drug therapy or physical therapy is ineffective. If the treatment is not effective, the scrotal scabies nodules can be surgically removed. Patients need to note that scrotal scabies nodules is a contagious disease, after the onset of the disease should be isolated as far as possible, and the clothes worn by the affected area need to be disinfected uniformly, so as not to cause the symptoms of infection in the surrounding people. In addition, it is recommended that patients pay attention to hygiene in daily life and wash the skin around the scrotum every day to keep the affected area clean and dry. At the same time, it is necessary to strengthen their immune system, exercise appropriately and maintain a positive and optimistic attitude towards treatment.