When stacking metronidazole gel and adapalene, the two medications can be applied more than 10 minutes apart. Metronidazole gel can be used as a topical treatment for inflammatory papules, impetigo, and rosacea erythema. Adapalene, on the other hand, can be used for the skin treatment of acne, papules, and pustules. For some patients when used to treat acne, the two medications can be used in a stack, where the application of metronidazole gel is followed by the application of adapalene gel at intervals of 10 minutes or more. Be careful to apply a thin layer of each medication, not too much, to avoid adverse reactions between the medications. Diet during treatment should be regular, do not eat too spicy, excessive food, chili, ice cream and other foods do not eat. In addition, the specific use of metronidazole gel and adapalene need to be taken under the guidance of a doctor.